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KMID : 0604520190450030319
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Journal of the Society of Cosmetic Scientists of Korea
2019 Volume.45 No. 3 p.319 ~ p.331
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Study of Optimized Extraction Conditions for Simultaneous Anti-inflammatory and Antioxidant Activity of Artemisia iwayomogi using Response Surface Methodology
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Park Da-Won
Choi Woo-Seok
Lee Chang-Hyeon
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Abstract
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This study was conducted to find a solvent, a extraction method and optimized conditions for Artemisia iwayomogi extract. which is effective to anti-inflammatory and antioxidant activity. A. iwayomogi extract by distilled water, ethanol, methanol, hexane and ethyl acetate using ultrasonic, high-pressure and supercritical extraction was investigated for NO inhibitory and DPPH radical scavenging activity. Extract obtained by ethanol and ultrasonic extraction method showed high NO production inhibitory activity, DPPH free radical scavenging activity and yield. Response surface methodology (RSM) was applied to find a optimized ultrasonic extraction conditions. Results showed that the optimum conditions for the higher yield were ethanol solvent of 45.71% concentration with extraction time and ultrasonic power of 63.33min and 308.84 W, respectively. This condition predicted 15.85% yield, but real yield was 16.40 ± 0.28%.
The optimum conditions for simultaneous anti-inflammatory and antioxidant activity were established as ethanol concentration (80.81%), extraction time (90.00 min) and ultrasonic power (400.00 W). NO production inhibitory and antioxidant activity were 89.77 ± 1.37% and 60.12 ± 0.39%, respectively. These results showed similar to the predicted values of 94.54%, 58.03% respectively.
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KEYWORD
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Artemisia iwayomogi, extraction, response surface methodology (RSM), anti-inflammation, antioxidan
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